Third-party lab tested
•
Transparent dosing
•
PubMed-indexed citations
•
Third-party lab tested
•
Transparent dosing
•
PubMed-indexed citations

By the numbers

The figures below are findings from the published Chandrasekhar et al. (2012) trial on 600mg KSM-66® ashwagandha — the exact extract and dose in F·02. They describe the study results, not a guaranteed individual outcome.

28%

Reduction in serum cortisol vs. placebo (P=0.0006)

44%

Reduction in Perceived Stress Scale scores

72%

Improvement on the GHQ-28 stress measure

72%

Reduction on the Depression Anxiety Stress Scale (DASS)

All figures from Chandrasekhar K, Kapoor J, Anishetty S, "A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root," Indian Journal of Psychological Medicine, 2012;34(3):255-262. 60-day study, n=64. Results reflect the study population and are not a guarantee of individual results.

What the research actually shows

We organized the evidence by what it can — and can't — claim. Strong evidence gets a strong statement. Emerging evidence gets an honest one.

Strong evidence · 4+ RCTs

600mg of KSM-66® significantly lowered serum cortisol in a 60-day double-blind trial.

In the landmark Chandrasekhar et al. (2012) randomized, double-blind, placebo-controlled study, 64 chronically stressed adults took 600mg/day of KSM-66® ashwagandha for 60 days. The treatment group showed a 27.9% reduction in serum cortisol versus placebo (P=0.0006), alongside significant improvements across every stress-assessment scale used.

This is the exact extract and the exact dose in F·02. We didn't round down to save on cost-of-goods.

Chandrasekhar K, Kapoor J, Anishetty S. Indian J Psychol Med. 2012;34(3):255-262.

Read the study on PubMed →
Strong evidence · Mechanism established

Ashwagandha works by regulating the stress axis itself — not by sedating you.

The hypothalamic-pituitary-adrenal (HPA) axis is your body's central stress-control system. Under chronic load, it overproduces cortisol — disrupting sleep, suppressing luteal-phase progesterone, and impairing working memory. Ashwagandha's withanolides act directly on this axis to normalize cortisol output, rather than masking symptoms the way a stimulant or sedative would.

Multiple independent RCTs have replicated this cortisol-lowering effect across different stressed populations. This is one of the most robust findings in the adaptogen literature.

Lopresti AL et al. Medicine (Baltimore). 2019;98(37):e17186.

Read the study →
Emerging evidence · Promising, dose-dependent

Lion's Mane improved cognition in clinical trials — at higher doses than any single supplement provides.

We're going to be honest here, because you'll check anyway. The strongest Lion's Mane data (Mori et al., 2009) used 250mg three times daily over 16 weeks in adults with mild cognitive impairment, and showed significant improvement on cognitive scales. A 2023 trial (Docherty et al.) found faster processing speed in healthy young adults at 1.8g.

F·01 uses Lion's Mane as a supporting compound, not at clinical dose. We include it for its mechanism — NGF stimulation and BDNF support — and we're not going to pretend 100mg replicates a 750mg trial. Its role in the formula is structural and cumulative, alongside Alpha-GPC and B12.

Mori K et al. Phytother Res. 2009;23(3):367-372. · Docherty S et al. Nutrients. 2023;15(22):4842.

Read the studies →
Established mechanism · Cognitive support

Alpha-GPC is a direct precursor to acetylcholine — the neurotransmitter of focus and memory.

Acetylcholine is central to attention, learning, and working memory. Alpha-GPC (alpha-glycerophosphocholine) is one of the most bioavailable choline sources and has been studied in cognitive-support and clinical-recovery contexts. In F·01 it works synergistically with L-Tyrosine — a dopamine and norepinephrine precursor that supports cognitive performance specifically under stress and fatigue.

Together they form the "acute clarity" layer of the morning formula: fast-acting, sublingually absorbed, and active within the first hour.

Parker AG et al. J Int Soc Sports Nutr. 2015;12(Suppl 1):P41.

Read the research →
The formulas

Every ingredient. Every reason.

Six key compounds across two formulas — with the evidence tier stated honestly. No proprietary blends. No borrowed credibility.
F·02 · 7PM

KSM-66® Ashwagandha

600 mg · standardized 5% withanolides
4+ RCTs
Strong evidence
F·01 · 9AM

Lion's Mane Mushroom

100 mg · sublingual
8+ human studies
Emerging evidence
F·01 · 9AM

Alpha-GPC

25 mg · sublingual
10+ cognitive studies
Established mechanism
F·01 · 9AM

L-Tyrosine

25 mg · sublingual
12+ human studies
Emerging evidence
F·02 · 7PM

Vitamin B6 + B12

2.5 mg B6 · 25 mcg B12 (methylcobalamin)
Established essentials
Strong evidence
F·02 · 7PM

Shatavari + Maca

50 mg Shatavari · 150 mg Maca
6+ human studies
Emerging evidence
Evidence tiers reflect the published research at the doses used in each formula. "Strong" = multiple RCTs at matching dose. "Emerging" = promising human data, often at higher doses. "Established mechanism" = well-documented biochemical pathway.

The women using Clarix.

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All the references in one place

Every study we cite, linked directly. Read the research here.

Shop the formulas

Find the answers to the most common questions

  • Because we'd rather be honest than oversell. F·02 (the capsules) is our clinical-dose product — KSM-66® at 600mg matches the trials exactly. F·01 (the drops) is a fast-acting morning ritual built around B12, Alpha-GPC, and L-Tyrosine, with mushrooms in a supporting role below clinical threshold. We tell you this on the label and on this page. A brand hiding behind a proprietary blend wouldn't.

  • Some ashwagandha research is funded by KSM-66's manufacturer (Ixoreal Biomed) — this is common and disclosed in the papers. But the Chandrasekhar 2012 trial is independently published in the peer-reviewed Indian Journal of Psychological Medicine, and the cortisol-lowering effect has been replicated by independent teams (e.g. Lopresti 2019). We link both so you can judge the funding sources yourself.

  • Fair. We use a tiered honesty system: "Strong" means multiple RCTs at matching doses. "Emerging" means promising human data, often at higher doses than a single product provides. "Mechanistic" means the biological pathway is established but human outcome data is still thin.

    We include emerging-evidence ingredients because the mechanism is sound and the safety profile is strong — but we'd rather label them honestly than dress them up. You're an adult. You can weigh "emerging."

  • The KSM-66 trials measured outcomes at 60 days. Ashwagandha is an adaptogen — it modulates the HPA axis over weeks, not in a single dose. Realistic expectation for F·02: meaningful change at weeks 4-8. F·01's amino acids and B12 act faster — often within the first hour of a dose — but the cumulative effects build over 6-8 weeks too.

    If you want something you feel in 20 minutes, that's caffeine, and we're not trying to replace it for the wrong reasons.

  • The trials measured effects during active supplementation. Like most adaptogens, the evidence supports ongoing use for ongoing benefit — the cortisol regulation reflects the body adapting while the compound is present. We're not aware of strong data on lasting effects after discontinuation, and we won't claim there are.

  • Don't. Trust the studies. That's why every figure on this page is linked to its primary source on PubMed or PMC. We've tried to represent the evidence accurately — including its limits — but you can verify every number yourself in about ten minutes. That's the whole point of building it this way.